anastrozole will increase the amount or result of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. slight/importance unidentified.

Monitor carefully (1)nevirapine will lessen the extent or effect of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/keep track of. For clients receiving exemestane that has a powerful CYP3A4 inducer the advised dose of exemestane is 50 mg everyday after a food.

estropipate decreases results of exemestane by pharmacodynamic antagonism. Use Caution/keep an eye on. Estrogens or estrogen-that contains products, together with combined oral contraceptives, really should not be offered concomitantly with exemestane; these medications could interfere While using the pharmacologic action and efficacy of exemestane.

Over time, excessive bone reduction could cause bones to be weak and brittle. This may increase your hazard of bone fractures.

check intently (one)istradefylline will boost the check here stage or influence of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Exemestane is dispersed thoroughly into tissues. Exemestane is 90% sure to plasma proteins as well as the portion sure is independent of the full concentration.

estrogens esterified decreases outcomes of exemestane by pharmacodynamic antagonism. Use warning/keep an eye on. Estrogens or estrogen-containing products, including merged oral contraceptives, really should not be specified concomitantly with exemestane; these prescription drugs could interfere While using the pharmacologic action and efficacy of exemestane.

Aromasin isn't authorised to be used in males* to treat breast cancer right now. for this reason, it’s not known just what exactly Unwanted effects that males getting this medication can have.

deferasirox will lower the extent or effect of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.

Coadministration of encorafenib with delicate CYP3A4 substrates might cause elevated toxicity or diminished efficacy of these brokers.

Exemestane is thoroughly metabolized by CYP 3A4, but coadministration of ketoconazole, a potent inhibitor of CYP 3A4, has no considerable impact on exemestane pharmacokinetics. considerable pharmacokinetic interactions mediated by inhibition of CYP isoenzymes hence look not likely.

are breastfeeding or decide to breastfeed. It is far from known if AROMASIN passes into your breast milk. don't breast-feed through procedure with AROMASIN and for 1 thirty day period following your last dose of AROMASIN.

efavirenz will reduce the extent or effect of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/watch. For people obtaining exemestane having a powerful CYP3A4 inducer the recommended dose of exemestane is fifty mg day by day after a food.

A period III demo was reported in 2011, concluding that the usage of exemestane in postmenopausal Girls at a heightened risk for breast cancer decreased the incidence of invasive breast most cancers.